{"id":2013,"date":"2023-02-22T14:46:20","date_gmt":"2023-02-22T14:46:20","guid":{"rendered":"https:\/\/www.stepharmaceuticals.com\/2023\/02\/22\/vitamin-d-deficiency-is-associated-with-increased-covid-19-severity-and-mortality\/"},"modified":"2024-07-01T10:34:06","modified_gmt":"2024-07-01T10:34:06","slug":"vitamin-d-deficiency-is-associated-with-increased-covid-19-severity-and-mortality","status":"publish","type":"post","link":"https:\/\/www.stepharmaceuticals.com\/es\/2023\/02\/22\/vitamin-d-deficiency-is-associated-with-increased-covid-19-severity-and-mortality\/","title":{"rendered":"Vitamin D deficiency is associated with increased COVID-19 severity and mortality"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00bb1&#8243; disabled_on=\u00bbon|on|on\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb0px||0px||false|false\u00bb disabled=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb100%\u00bb max_width=\u00bb100%\u00bb custom_padding=\u00bb0px||0px||false|false\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text admin_label=\u00bbSTE PHARMACEUTICALS.ES\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bb#00a6ce\u00bb custom_margin=\u00bb||0px||false|false\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p style=\"text-align: center;\"><a style=\"color: #fff;\" href=\"https:\/\/www.stepharmaceuticals.com\/es\/\">visit <strong>STE PHARMACEUTICALS.ES<\/strong><\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.24.2&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb200px||||false|false\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb background_enable_image=\u00bboff\u00bb sticky_enabled=\u00bb0&#8243;][et_pb_row _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb100%\u00bb max_width=\u00bb100%\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text admin_label=\u00bbLAST NEWS FROM STE PHARMACEUTICALS\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb header_font_size=\u00bb22px\u00bb custom_margin=\u00bb||15px||false|false\u00bb custom_css_main_element=\u00bbfont-family: %22Open Sans%22,arial,sans-serif;\u00bb global_colors_info=\u00bb{}\u00bb]<a href=\"https:\/\/www.stepharmaceuticals.com\/blog\/\"><\/p>\n<h1 style=\"color: #00a6ce; font-weight: bold; text-align: center;\">LAST NEWS FROM STE PHARMACEUTICALS<\/h1>\n<p><\/a>[\/et_pb_text][et_pb_text admin_label=\u00bbProgress Mindset\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb header_2_font_size=\u00bb54px\u00bb custom_css_main_element=\u00bbfont-family: %22Open Sans%22,arial,sans-serif;\u00bb global_colors_info=\u00bb{}\u00bb]<a href=\"https:\/\/www.stepharmaceuticals.com\/blog\/\"><\/p>\n<h2 style=\"color: #000; font-weight: bold; text-align: center;\">Progress Mindset<\/h2>\n<p><\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.24.2&#8243; _module_preset=\u00bbdefault\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb background_enable_image=\u00bboff\u00bb sticky_enabled=\u00bb0&#8243;][et_pb_row _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text admin_label=\u00bbVitamin D deficiency is associated with increased COVID-19 severity and mortality (titulo)\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb header_2_font_size=\u00bb38px\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h1 style=\"text-align: center; color: #00a6ce;\">Vitamin D deficiency is associated with increased COVID-19 severity and mortality<\/h1>\n<p>[\/et_pb_text][et_pb_text admin_label=\u00bbPublished on : 23 de September de 2022 by STE Pharmaceuticals blog<\/p>\n<p>\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb custom_css_main_element=\u00bbtext-transform: uppercase;||letter-spacing: 2px;||font-size: 12px;||font-weight: normal;\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p style=\"text-align: center;\"><a style=\"color: #000; text-align: center;\" href=\"https:\/\/www.stepharmaceuticals.com\/2023\/02\/22\">Published on : 23 de September de 2022 by STE Pharmaceuticals blog<\/a><\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=\u00bbIMAGEN\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb custom_css_main_element=\u00bbclip-path: circle();\u00bb border_radii=\u00bbon|20px|20px|20px|20px\u00bb global_colors_info=\u00bb{}\u00bb]<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-744 size-full aligncenter\" src=\"https:\/\/www.stepharmaceuticals.com\/wp-content\/uploads\/2023\/02\/VITAMIN-D.png\" alt=\"\" width=\"400\" height=\"400\" srcset=\"https:\/\/www.stepharmaceuticals.com\/wp-content\/uploads\/2023\/02\/VITAMIN-D.png 400w, https:\/\/www.stepharmaceuticals.com\/wp-content\/uploads\/2023\/02\/VITAMIN-D-300x300.png 300w, https:\/\/www.stepharmaceuticals.com\/wp-content\/uploads\/2023\/02\/VITAMIN-D-150x150.png 150w, https:\/\/www.stepharmaceuticals.com\/wp-content\/uploads\/2023\/02\/VITAMIN-D-100x100.png 100w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/>[\/et_pb_text][et_pb_text admin_label=\u00bbOptimal vitamin D levels help in reducing the susceptibility to respiratory infections and might be useful for the treatment of people who become infected with COVID-19. (titulo)\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h4><strong>  Optimal vitamin D levels help in reducing the susceptibility to respiratory infections and might be useful for the treatment of people who become infected with COVID-19.<\/strong><\/h4>\n<p>[\/et_pb_text][et_pb_text admin_label=\u00bbVitamin D is important for bone health&#8230;\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p>Vitamin D is important for bone health, but it also has a role as an essential immunologic mediator having inhibitory effects on the production of pro-inflammatory cytokines, including TNF-alpha and IL-6. Therefore, low vitamin D status has been associated with a range of autoimmune, cardiovascular, and infectious diseases like influenza and respiratory viruses, including COVID-19 infection<sup>1<\/sup>.<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=\u00bbVitamin D can be produced in the skin through&#8230;.\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p>Vitamin D can be produced in the skin through exposure to sunlight and, a person can also boost their vitamin D intake through certain foods or by taking vitamin D supplements. Vitamin D supplementation helps in reducing the susceptibility of developing flu by acting as a physical barrier against the infection, or through modulation of natural and\/or adaptive immunity mechanisms to reduce the risk of infection. Vitamin D supplementation might be also useful to increase vitamin D levels for the treatment of people who become infected with COVID-19<sup>2<\/sup>.<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=\u00bbVitamin D deficiency pre-COVID-19 infection increases disease severity and mortality risk (titulo)\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h4><strong>Vitamin D deficiency pre-COVID-19 infection increases disease severity and mortality risk<\/strong><\/h4>\n<p>[\/et_pb_text][et_pb_text admin_label=\u00bbA retrospective study has demonstrated&#8230;.\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p>A retrospective study has demonstrated a correlation between deficiency of vitamin D before COVID-19 infection and increased COVID-19 severity and mortality during hospitalization. The study led by Amiel A. Dror, for the Department of Otolaryngology, Head and Neck Surgery of the Galilee Medical Center (Nahariya, Israel) examined the relationship between pre-infection serum level of 25-hydroxyvitamin D (25(OH)D) and disease severity and mortality due to SARS-CoV-2<sup>3<\/sup>.<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=\u00bbThe authors evaluated 253&#8230;\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p>The authors evaluated 253 medical records of individuals with positive polymerase chain reaction (PCR) tests for SARS-CoV-2 and records of a 25(OH)D level before COVID-19 infection.<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=\u00bbVitamin D deficiency was associated&#8230;.\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<p>Vitamin D deficiency was associated with both severity and mortality of COVID-19 disease. Based on vitamin D levels prior to COVID-19 infection, patients with vitamin D deficiency (&lt;20 ng\/mL) were 14 times more likely to have severe or critical disease than patients with 25(OH)D \u2265 40 ng\/mL (OR 14; 95% CI 4 to 51; p &lt; 0.001).<\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=\u00bbVitamin D supplementation (titulo)\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<\/p>\n<h4><strong>Vitamin D supplementation<\/strong><\/h4>\n<p>[\/et_pb_text][et_pb_text admin_label=\u00bbHaving adequate vitamin D levels&#8230;\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]Having adequate vitamin D levels helps improve general immunity and prevent some immune disorders. Daily vitamin D supplementation has been proven effective to increase vitamin D levels and reach the optimal level of 40-60 mg\/mL.<\/p>\n<p><strong>STE Pharmaceuticals offers a range of vitamin D3 supplement products, for vitamin D deficiency or as a dietary supplement:<\/strong><\/p>\n<p><a style=\"color: #000;\" href=\"https:\/\/www.stepharmaceuticals.com\/producto\/vitamin-d3\">Vitalynk D3 oral spray<\/a>, <a style=\"color: #000;\" href=\"https:\/\/www.stepharmaceuticals.com\/?post_type=product&#038;p=2381\">Vitalynk D3 forte oral spray <\/a>and <a style=\"color: #000;\" href=\"https:\/\/www.stepharmaceuticals.com\/producto\/vitamin-d3-drops\">Vitalynk D3 drops,<\/a> food supplements based on vitamin D, which contributes to the normal function of the immune system and the maintenance of normal bones and muscle function.<\/p>\n<p><a style=\"color: #000;\" href=\"https:\/\/www.stepharmaceuticals.com\/producto\/vitamin-d3k2-drops\">Vitalynk D3+K2 drops<\/a>, food supplement based on vitamin D and vitamin K. Vitamin K contributes to the maintenance of normal bones and normal blood clotting.<\/p>\n<p>Both spray and drops are practical and innovative presentations that enable to reach the optimal level of vitamin D.[\/et_pb_text][et_pb_text admin_label=\u00bbHaving adequate vitamin D levels&#8230;\u00bb _builder_version=\u00bb4.19.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb]<strong>Reference<\/strong><\/p>\n<ol>\n<li>Charoenngam N, Holick MF. Immunologic effects of vitamin d on human health and disease. Nutrients. 2020;12(7):2097<\/li>\n<li>Grant WB, Lahore H, McDonnell SL, et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020; 12(4):988<\/li>\n<li>Dror AA, Morozov N, Daoud A, et al. Pre-infection 25-hydroxyvitamin D3 levels and assciation with severity of COVID-19 illness. 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